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22602 Colitis--Treatment : , 2538. 20 . 97979 ; Collaboration Arphorn Chuaprapaisilp. A study of the process and outcomes of collaboration between nursing service and nursing education in Thailand. Songkhla : Faculty of Nursing, Prince of Songkla University, 1996. 30 p. R E10533 ; Collagen Choowong Auesukaree. Analysis of binding region of HSP47 on type I collagen. Kyoto : Kyoto University, [1998]. 1 vol in various pagings ; . R E11942 ; Neeracha Ruangpanit. Collagen requirements of cell surface activation of gelatinase A by fibroblasts. Bangkok : Chulalongkorn University, 2000. 168 p. T E16855 ; Wilaiwan Chotigeat. Nature of collagen in hamster livers infected with Opisthorchis viverrini. Bangkok : Mahidol University, 1984. 2 microfiches 111 fr. ; . T MF19983 ; Collective behavior Kanda Pooput. An investigation of the relationships among personal resources, coping styles, and depression in college students. Columbia : University of Missouri-Columbia, 1992. x, 122 p. T E8217 ; College administrators Bampen Phongphetdit. Factors relating to the success of ISO 9000 implementation at Nursing Colleges of Pra-Borommarajanock Institute, Ministry of Public Health. Bangkok : Mahidol University, 2000. 221 p. T E15302 ; Fontip Mulpramook. A study of the leadership behaviors of public university administrators as perceived by faculty members in Bangkok. Bangkok : Mahidol University, 2001. 103 p. T E16887 ; Tipawan Prasertphan. The role of department chairpersons in teacher colleges in Thailand. Edmonton : University of Alberta, 1994. 243 p. T E7792 ; College administrators--Bangkok : , 2541. 93 . 98697.
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Between chimpanzees and humans lies much less in the changes in the particular cell types--muscle, cartilage, skin, and so on--than in their spatial organization. Direct confirmation of this comes from studies which compare the proteins of humans and apes. If we look at the genes that code for the average `housekeeping' proteins--proteins that function as enzymes or provide basic cell structure and movement--the similarity between chimpanzees and humans is greater than ninety-nine percent. The difference must reside not in the building blocks but in how they are arranged, and these are controlled by regulatory genes controlling pattern and growth. 16. A more concise way of explaining this would be to say that biological organisms are non-linear complex systems and thus small differences between them negate extrapolation. There are biochemical reasons for questioning the extrapolation of the results of experiments on animals to humans. Evolutionary biology supports and explains these reasons. Small differences between species' genes lead to huge differences at the molecular level, which is where we focus when treating disease. This is the crux of our argument; that small variations on the genetic level not only define a species but also confound the ability of one species to `model' another in aspects such as disease mechanisms and drug effects. 17. Mark Ptashne and Alexander Gann write in Genes & Signals: is generally believed that mammals--humans and mice, for example-- contain to a large extent the same genes; it is the differences in how these genes are expressed that account for the distinctive features of the animals. a relatively small number of genes and signals have generated an astounding panoply of organisms. Thus, the regulatory machinery must be such that it readily throws up variations--new patterns of gene expression--for selection to work on. 18. Same genes, but slightly different regulation. More complex organisms were built from the pieces of older organisms. Evolution took advantage of preexisting materials and constructed new organisms to fill a niche. Humans were not made ex nihilo, but rather evolution took a piece of an enzyme from a predecessor and, for example, serophene clomiphene. Hormones and steroids a somewhat more recent major discovery of a plant compound of medical interest than those discussed so far occurred in the 1940s.
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