In the late 1990's the Caribbean Food and Nutrition Institute CFNI ; developed an informal training manual for primary health-care providers on the dietary management of diabetes. This was successfully adopted by many of the region's health-care providers. Indeed, widespread demand for the manual suggested the need for the development of a formal protocol. As a result, in collaboration with the Caribbean Program Coordination Office of the Pan American Health Organization PAHO ; and the Ministry of Health in Jamaica, CFNI embarked on the development of a regional protocol for the nutritional management of diabetes, obesity and high blood pressure hypertension ; . Objectives: care and quality of life The main goals of the protocol were to improve the standards of care for all people with diabetes in the Caribbean region, and thus to.
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Your family and friends may have little understanding of infertility, what you are going through, or how they can help you. Remember, before you began treatment, how much did you know about infertility? You may want to share the following suggestions with people significant to you. Their understanding and sensitivity can form a strong and cohesive support network for you and your partner. Learn about Infertility For most couples experiencing infertility, making a baby does not include passion or romance. Their only hope for a biological child lies with medical treatment that can be very stressful, time consuming and expensive. Infertility is a medical condition that cannot be cured by relaxing taking a vacation or adopting a baby. Be Sensitive Invite the couple to all social gatherings and family functions. Even if the occasion is a baby shower, let them make the decision to attend or not. Be understanding if they choose not to go or they leave early. Be sensitive. Try not to center conversations around children or pregnancy. Avoid infertility clichs like "just relax and you'll get pregnant for sure" or "think of all the fun you have trying." Such comments are often perceived as thoughtless and uncaring by couples experiencing infertility. Show the couple you care about them and sympathize with the difficulties they have had trying to get pregnant. Let them talk about their fertility problems if they choose. Don't press for details or offer unsolicited advice. Ask how you can help. A ride to a doctor's visit, a casserole or an invitation to a movie can all show you care. Baby-sitting would certainly help a couple experiencing a secondary infertility. At times all they might need is a good listener or a hug. Maintain Confidentiality If the couple has shared their fertility problems with you, respect their confidence. They need to know they can trust you.
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1. 2. 3. McEvoy GK, ed. American Hospital Formulary Services, AHFS Drug Information. Bethesda, Md: American Society of Health-System Pharmacists; 2006. Starlix [package insert]. East Hanover, NJ: Novartis Pharmaceutical Corporation; January 2004. Pranfin [package insert]. Princeton, NJ: Novo Nordisk, Inc.; December 2004. Black C, McIntyre L, Mesa-Perez, et al. Meglitinide analogues for type 2 diabetes mellitus [protocol]. Cochrane Database of Systematic Reviews. 1, 2006. American Association of Clinical Endocrinologists AACE ; . Medical Guidelines for the Management of Diabetes Mellitus: The AACE System of Intensive Diabetes Self-Management2002 Update. Endocr Pract. 2002; 8 Suppl.1 ; : 40-82. American College of Endocrinologists ACE ; American Association of Clinical Endocrinologists AACE ; Diabetes Recommendations Implementation Conference: Road Map for the Prevention and Treatment of Type 2 Diabetes. Available from: aace meetings consensus odimplementation roadmap . Accessed on July 12, 2006. International Diabetes Federation IDF ; Clinical Guidelines Task Force. Global Guideline for Type 2 Diabetes. Available at: : idf webdata docs IDF%20GGT2D . Accessed April 28, 2006. Institute for Clinical Systems Improvement. Healthcare Guideline: Management of Type 2 Diabetes Mellitus. 10th Ed. Available at: : icsi knowledge detail ?catID 29&itemID 182. Accessed April 28, 2006. National Institute for Clinical Excellence NICE ; . Type 2 diabetes - Management of blood glucose. Available at: : nice pdf NICE full blood glucose . Accessed April 28, 2006. Tatro DS, ed. Drug Interaction Facts. St. Louis, Mo: Wolters Kluwer Health, Inc.; 2006. Marion, DW. Nateglinide: drug information. In: Rose, BD, ed. UpToDate. Waltham, Mass: UpToDate, 2006. Marion, DW. Repaglinide: drug information. In: Rose, BD, ed. UpToDate. Waltham, Mass: UpToDate, 2006. Fonseca V, Grunberger G, Gupta S, et al. Diabetes Care. 2003; 26 6 ; : 1685-1690. Marre M, Van Gaal L, Usadel K-H, et al. Nateglinide improves glycemic control when added to metformin monotherapy: results of a randomized trial with type 2 diabetes patients. Diabetes Obes Metab. 2002; 4 3 ; 177-186. Rosenstock J, Hassman D, Madder R, et al. Repaglinide versus nateglinide monotherapy a randomized, Multicenter study. Diabetes Care. 2004; 27 6 ; : 1265-1270. Raskin P, Klaff L, McGill J, et al. Efficacy and safety of combination therapy repaglinide plus metformin versus nateglinide plus metformin. Diabetes Care. 2003; 26 7 ; : 2063-2068. Hollander P, Schwartz S, Gatlin M, et al. Importance of early insulin secretion comparison of nateglinide and glyburide in previously diet-treated patients with type 2 diabetes. Diabetes Care. 2003; 24 6 ; : 983-988. Wolffenbuttel B, Landgraf R. A 1-year Multicenter randomized double-blind comparison of repaglinide and glyburide for the treatment of type 2 diabetes. Diabetes Care. 1999; 22 3 ; : 463-467. Derosa G, Mugellini A, Ciccarelli L, et al. Comparison between repaglinide and glimepiride in patients with type 2 diabetes mellitus: a one-year, randomized, double-blind assessment of metabolic parameters and cardiovascular risk factors. Clin Ther. 2003; 25 2 ; : 472-484. Derosa G, Mugellini A, Ciccarelli L, et al. Comparison of glycemic control and cardiovascular risk profile in patients with type 2 diabetes during treatment with either repaglinide or metformin. Diabetes Res Clin Pract. 2003; 60 3 ; : 161-169 Gerich J, Raskin P, Jean-Louis L, et al. PRESERVE- Two-year efficacy and safety of initial combination therapy with nateglinide or glyburide plus metformin. Diabetes Care. 2003; 28 9 ; : 2093-2099. Horton E, Clinkingbeard C, Gatlin M, et al. Nateglinide alone and in combination with metformin improves glycemic control by reducing mealtime glucose levels in type 2 diabetes. Diabetes Care. 2000; 23 11 ; : 1660-1665. Moses R, Slobodniuk R, Boyages S, et al. Effect of repaglinide addition to metformin monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care. 1999; 22 1 ; : 119-124. Raskin P, McGill J, Saad MF, et al. Combination therapy for type 2 diabetes: repaglinide plus rosiglitazone. Diabet Med. 2004; 21 4 ; : 329-335.
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References from Therapeutic Class Review: 1. Clinical Pharmacology 2000, [cited 2003 Dec 29] 2. Drugsnikolov Drugs USPDI Micromedex ; 3. AHFS Drug Information 2002, 3018-3047 4. MerckMedicus Drug References GenRx Mosby's GenRx ; Drug Info Index 2002 5. Glipizide package insert, Mylan-US ; , Rev May 2001 6. Glimepride package insert, Aventis-US ; , Rev July 2001 7. Glyburide package insert, Geneva-US ; , Rev April 2002 8. Glucophage, Physicians Desk Reference 2002, 1080-1086 9. Precose package insert. Bayer Corporation. West Haven CT. 2001 10. Glyset package insert. Pharmacia & Upjohn Company. West Haven CT. 2002 11. Starlix package insert. Novartis Pharmaceutical. East Hanover NJ. December 2000 12. Randin package insert. Novo Nordisk Pharmaceuitical. Princetion, NJ. October 2002 13. Metaglip Package Insert. Bristol-Myers Squibb Company, Princeton, NJ 2002 14. Glucovance Package Insert. Bristol-Myers Squibb Company, Princeton, NJ 2002 15. Avandamet Package Insert. GlaxoSmithKline, Teserach Triangle Park, NC 2002 16. UK Prospective Diabetes Study UKPDS ; group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes. Lancet 1998; 352: 837-53. Schade DS, Jovanovic L, Schneider J. A placebo-controlled, randomized study of glimepiride in patients with type 2 diabetes mellitus for whom diet therapy in unsuccessful. J Clin Pharmacol 1998; 38: 636-641. Dills DG, Schneider J and The Glimepiride glyburide research group. Clinical evaluation of glimepiride versus glyburide in NIDDM in a double-blind comparative study. Horm Metab Res 1996; 28: 426-429. UK Prospective Diabetes Study UKPDS ; group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes UKPDS 34 ; . Lancet 1998; 352: 854-65. Diabetes prevention program research group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 345: 363-403. Fujioka K, Pans M, Joyal S. Glycemic control in patients with type 2 diabetes mellitus switched from twice-daily immediate release metformin to a once-daily extended-release formulation. Clinical Therapeutics 2003; 25 2 ; : 515-29. 22. Horton ES, Clinkingbeard C, Gatlin M, et al. Neteglinide alone and in combination with metformin improves glycemic control by reducing mealtime glucose levels in type 2 diabetes. Diabetes Care 2000; 23: 1660-1665. Jovanovic L, Dailey G, Huang WC, et al. Repaglinide in type 2 diabetes: a 24-week, fixed-dose efficacy and safety study. J Clin Pharmacol 2000; 40: 49-57. ACS 2 27 2004 Jonhston PS, Feig PU, Coniff RE, et al. Chronic treatment of African-American type 2 diabetic patients with -glucosidase inhibition. Diabetes Care 1998; 21 3 ; : 416-422. 25. Rosenstock J, Brown A, Fischer J, et al. Efficacy and safety of acarbose in metformin-treated patients with type 2 diabetes. Diabetes Care 1998; 21 12 ; : 20502055. 26. Chiasson JL, Josse RG, Gomis R, et al. Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA 2003; 290 4 ; : 486-94. 27. Fonseca V, Rosenstock J, Patwardhan R, et al. Effect of metformin and rosiglitazone combination therapy in patients with type 2 diabetes mellitus. JAMA 2000; 283: 16951702. Yki-Jarvinen H, Ryysy L, Nikkila K, et al. Comparison of bedtime insulin regimens in patients with type 2 diabetes mellitus. Ann Intern Med 1999; 130: 389-396. Goldstein BJ, Pans M, Rubin CJ. Multicenter, randomized, double-masked parallelgroup assessment of simultaneous glipizide metformin as second-line pharmacologic treatment for patients with type 2 diabetes mellitus that is inadequately controlled by a sulfonylurea. Clinical Therapeutics 2003; 25 3 ; : 890-903. 30. Hoffmann J, spengler M, et al. Efficacy of 24-week monotherapy with acarbose, metformin or placebo in dietary-treated NIDDM patients: the Essen II study. J Med 1997; 103 6 ; : 483-490. 31. Damsbo P, Caluson P, Marbury TC, et al. A double-blind randomized comparison of meal-related glycemic control by repaglinide and glyburide in well-controlled type 2 diabetic patients. Diabetes Care 1999; 22: 789-794. Hollander PA, Schwartz SL, Gatlin MR, et al. Importance of early insulin secretion: comparison of nateglinide and glyburide in previously diet-treated patients with type 2 diabetes. Diabetes Care 2001; 24: 983-988. Wlffenbuttel BHR, Landgraf R, Dutch and German Repaglinide Study Group. A 1year multicenter randomized double-blind comparison of repaglinide and glyburide for the treatment of type 2 diabetes. Diabetes Care 1999; 22: 463-467. Turner RC, Cull CA, Frighi V. et al. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus, progressive requirement for multiple therapies UKPDS 49 ; . JAMA 1999; 281 21 ; : 2005-2012 35. The DECODE Study Group, the European Diabetes Epidemiology Group. Glucose tolerance and cardiovascular mortality: comparison of fasting and 2-hour diagnostic criteria. Arch Int Med 2001; 16 3 ; : 397-405. 36. Inzucchi SE. Oral antihyperlgycemic therapy for type 2 diabetes. JAMA 2002; 287 3 ; : 360-372. 37. Electronic Orange Book July 2003 [cited 2003 Aug 29]. : fda.gov cder ob. 38. Garber AJ, Donovan DS, Dandona P, et al. Efficacy of glyburide metformin tablets compared with initial monotherapy in type 2 diabetes. Journal of Clinical Endocrinology & Metabolism 2003; 88 8 ; : 3598-604. 39. Drug Facts and Comparisons 2000. Endocrine and Metabolic Agents [cited 2003 Dec 22]. : efactsweb and progesterone and prandin.
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