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All experiments were approved by the Institutional Animal Care and Use Committee at Cornell University and conducted in accordance with NIH National Institutes of Health ; Guidelines for Animal Care. WT, GPX1 [5] and SOD1 [4] mice were derived from 129 SVJ C57BL 6 lines and provided by Dr Y. Ho, Wayne State University Detroit, MI, U.S.A. ; . The DKO mice were generated by crossing the GPX1 and SOD1 mice in our facility. Deletion of GPX1 and SOD1 genes in different genotypes was verified by PCR using tail DNA as templates, and by respective enzyme activity assays in various tissues. Liver GPX1 or SOD1 activities in the respective knockout mice were 1 % of the WT mice. Mice were housed in shoebox cages in a room at a constant temperature 22 C ; with a 12 h light dark cycle and were given free access to food and distilled water. In the first survival study, WT, SOD1 , GPX1 and DKO male mice 8-week-old, n 810 per group ; were given an intraperitoneal injection of PBS or 600 mg of APAP kg of body mass prepared in warm PBS ; following an overnight fast 8 h ; . After the injection, mice were observed regularly for 70 h. Two additional survival experiments were conducted with only WT and SOD1 mice to assess the impact of SOD1 deletion on mouse survival after injection of a lower dose 300 mg of APAP kg ; and a higher dose 1200 mg of APAP kg; n 6 for each dose genotype ; . In the biochemical and APAP metabolism studies, WT and SOD1 mice were injected with 600 or 300 mg of APAP kg and killed at various time points 024 h, n 46 per genotype at each time point ; post-injection to collect plasma and liver samples. All samples were frozen in liquid nitrogen and stored at - 80 C before analysis, because isosorbide 5 mononitrate.
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From the dorsal region of each sacrificed rat. The excised rat skins were stored at 80-C. The skin membranes were first hydrated for 30 minutes in the buffer solution pH 7.4 ; at room temperature 23-C ; to remove extraneous debris and leachable enzymes.7 They were then placed between the donor and receptor compartments of the cells, with the dermal side in direct contact with the receptor medium. Approximately 20 mL of phosphate buffer pH 7.4 ; was placed in the receptor compartment. Its temperature was maintained at 37 0.5-C using a thermostatic water bath Variomag, Munich, Germany ; , and it was stirred at 600 rpm throughout the experiment. The donor compartment contained 1 g of the sample. The aliquots 0.7 mL ; were withdrawn at predetermined time intervals and then immediately analyzed spectrophotometrically at 277 nm against a blank prepared with the permeated formulation M, M + DMSO, or G ; without the drug.16, 17 The same amount of fresh buffer was added to the receptor compartment to replace what had been removed. Three replicates of each experiment were performed. Determination of Drug Solubility To determine the drug solubility, an excess amount of DS was added to distilled water. This suspension was stirred at room temperature for 24 hours with a magnetic stirrer. The sample was then filtered through a 0.45-m cellulose acetate filter Sartorius AG, Goettingen, Germany ; . The concentration of DS was determined spectrophotometrically at 277 nm.18, 19.
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Breast-feed their babies natural lactation ; . The plants cited for treating this problem are used to improve the quality and the quantity of the mother's milk. The "child-cross" ailment is specific to the Dja area Betti, 1994 ; . This ailment is characterized by the lose of weight, and occurs on the baby between 1 and 10 months ; when the two parents have not respected certain rituals before sex party. II. Habitat Preference of the Plants Cited Forest plants of primary and secondary forests are more represented as medicines in terms of number of species. They comprise 78% of the medicinal plants collected. This may be due to the location of Dja Reserve in the forest area. Forests have richer flora than open savannah areas Bouquet, 1969; Bitsindou, 1996 ; . According to Evrard 1968 ; , the forest areas have a great number of large plant species in the top or higher strata. Another reason for the large proportion of forest plants is that they have more active secondary compounds than cultivated plants. Also, there is a local belief that forest trees possess some mystical curative powers, because they grow in dark, wild natural habitats. This is why traditional healers prefer forest plants to cultivated plants Rosoanaivo cited by Bitsindou, 1996 ; for healing. However, logging, large-scale agriculture and other human activities in the area are leading to the degradation of primary forests UICN, 1989; Betti, 2002c ; , thus causing "vulnerability" of the wild plants. III. Relative Importance of Medicinal Plants The plants used by the Baka were compared with the plants used in other parts of Africa, mostly in the following seven countries of central Africa: Cameroon, Congo, Gabon, Equatorial Guinea, Central African Republic, Democratic Republic of Congo, and Rwanda. These countries were selected because they belong to the same Guinean-Congolian Forest area Lebrun, 1947 ; inhabited by the Baka. They share many common plants. Similarities in medicinal plant uses in countries such as Nigeria, Senegal, and Togo in West Africa were also found. All the information obtained from the survey is given in Appendix 4. A total of 51 plants frequently used Ip 0 ; by the Baka females mothers ; are also used in other regions of Cameroon and or in other African countries for similar ailments Appendix 4 ; . Six plants are used in at least four countries: Chenopodium ambrosioides for treating intestinal helminthiasis, in 9 countries ; , Alstonia boonei malaria, 7 countries ; , Picralima nitida intestinal helminthiasis, 6 countries ; , Mangifera indica diarrhoea, 4 countries ; , Ocimum gratissimum cough, 4 countries ; , Psidium guajava diarrhoea, 4 countries ; . The following 8 plants are cited in 3 countries: Alchornea cordifolia for treating toothache ; , Capsicum frutescens cough ; , Carica papaya toothache ; , Enantia chlorantha malaria ; , Milicia excelsa lactation failure ; , Picralima nitida malaria ; , Pterocarpus soyauxii scabies ; , and Vernonia amygdalina malaria ; . It is notewor.
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Table 1: Antibiotic susceptibility of environmental isolates of Campylobacter, by disc diffusion method Campylobacter No. of spp. isolates C. jejuni C. coli C. lari 27 18 25 % Campylobacter isolates sensitive to Ka Co 70.3 29.7 32 0 0 100 Er 59.2 33.4 44 Ge 74 38.9 32 and isoflavone.
Ease in a cohort of young North Americans after a 26 year observation period: The Manitoba Study. J Cardiol. 1977; 39: 452458. Larsson B, Svardsudd K, Welin L, et al. Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow-up of participants in the Study of Men Born in 1913. BMJ. 1984; 288: 14011404. Yater WM, Traum AH, Spring S, et al. Coronary artery disease in men eighteen to thirty-nine years of age. Heart J. 1948; 36: 334372. Lee KT, Thomas WA. Relationship of body weight to acute myocardial infarction. Heart J. 1956; 52: 581591. Kissebah AH. Insulin resistance in visceral obesity. Int J Obes. 1991; 15: 109115. Despres JP, Lamarche B, Mauriege P, et al. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med. 1996; 334: 952957. Despres JP, Moorjam S, Lupien PJ, et al. Regional distribution of body fat, plasma lipoproteins and cardiovascular disease. Arteriosclerosis. 1990; 10: 497511. Steingberg HO, Chaker H, Learning R, et al. Obesity insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest. 1996; 97: 26012610. Cigolini M, Targher G, Bergamo Andreis IA, et al. Visceral fat accumulation and its relation to plasma hemostatic factors in healthy men. Arterioscler Thromb Vasc Biol. 1996; 16: 368374. Anellone G, DiGarbo V, Cardova R, et al. Blood coagulation and fibrinolysis in obese NIDDM patients. Diabetes Res. 1994; 25: 8592. Folsom AR, Qamhieh HT, Wing RR, et al. Impact of weight loss on plasminogen activator inhibitor PAI1 ; , factor VII, and other hemostatic factors in moderately overweight adults. Arterioscler Thromb. 1993; 13: 162169. Wallace AM, McMahon AD, Packard CJ, et al. Plasma leptin and the risk of cardiovascular disease in the West of Scotland Coronary Prevention Studies WOSCOPS ; . Circulation. 2001; 104: 30523056. Fujioka S, Matsuzawa Y, Tokunaga K, et al. Improvement of glucose and lipid metabolism associated with selective reduction of intra-abdominal visceral fat in premenopausal women with visceral obesity. Int J Obes. 1991; 15: 853859. Fox AA, Thompson IL, Butterfield GE, et al. Effects of diet and exercise on common cardiovascular disease risk factors in moderately obese older women. J Clin Nutr. 1996; 63: 225233.
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EDUCATING MOTHERS CAN ALTER CHILDREN'S OSTEOPOROSIS PREVENTIVE BEHAVIOURS T Winzenberg1, B Oldenburg3, S Frendin2, L De Wit1 & G Jones1 1 Menzies Research Institute, Hobart, TAS 2 Department of Health and Human Services, Hobart, TAS 3 Queensland University of Technology, Brisbane, QLD Childhood represents a unique opportunity to increase bone mass. However, data on methods of changing osteoporosis preventive behaviour in children is sparse. This study aimed to assess whether an educational intervention delivered to mothers might impact on their children. As part of a randomized trial in 470 premenopausal women examining the impact of bone density feedback with either an osteoporosis information leaflet, or a group education intervention, we assessed mothers self-report of calcium intake and physical activity change in their children. Change in children's calcium intake at 2 years was associated with having a child aged less than 18 years OR 4.3, 95%CI 1.1, ; , receiving small group education OR 2.3, 95%CI 1.4, ; and receiving feedback of a low T-score result OR 2.0, 95%CI 1.2, ; . Increases in children's calcium intake were more likely in mothers who commenced calcium supplements OR 2.6, 95%CI 1.0, ; or increased their own self-reported physical activity OR 2.2, 95%CI 1.3, ; . Mothers who reported increases in their own physical activity were also more likely to report increases in that of their children OR 2.7, 95% CI 1.5, 5.0 ; . In conclusion, both BMD feedback and small group education aimed specifically at women are effective at inducing self-reported osteoporosis preventive behaviour change in their children. While this effect is most obvious if the woman alters her own behaviour, there is also an independent effect on the child regardless of behavioural change in the mother.
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Dad sent me a clipping from the LA Times describing a similar practice in California. Evidently, a Ms. Chavez - deep in the throes of labor - told her doctor to begin the epidural for the pain. The nurse came in and said, "That will be $400, " to which the patient said, "Sure, no problem." "No, you don't understand, " the nurse replied, "I need $400 now." "Her asthma kicking in, " the article reports, "hardly able to breathe, Chavez asked her husband to write a check." But the anesthesiologist refused to accept it. The anesthesiologist also refused her credit cards. So Chavez had her mother wire cash in from England, but the anesthesiologist wouldn't accept the confirmation number from Western Union as proof that the money was on the way. The nurse noted in the chart, "Pt. unable to pay cash." Chavez had Medi-Cal, California's version of Medicaid, which reimburses doctors $57 for the initial insertion of the epidural, and about a dollar a minute after that. The anesthesiologist's attorney described this amount as, "so nominal it's nothing." Not to let suffering get in the way of making more money, "some doctors suggested that anesthesiologists should refuse to accept Medi-Cal recipients as patients even if it means leaving them in pain on the delivery table."[143] Which is exactly what happened.
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