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BACKGROUND The prevalence of transplant CAD detected by angiography at 1, 2 and 4 years after heart transplantation was 11%, 22% and 45%, respectively. The incidence of transplant CAD in Chinese heart recipients has not been reported. METHODS For those recipients surviving for more than 1 year after transplantation, coronary angiography was performed annually for surveillance of transplant CAD. The recipient characteristics, donor characteristics, rejection episodes, medication and human leukocyte antigen HLA ; mismatches were recorded. Fifty patients were included in this study. Thirteen 26% ; recipients had ischemic heart disease. Two patients 4% ; had active cytomegalovirus CMV ; infection after transplantation. The mean number of rejection episodes in the 1st year after transplantation was 1.15. Among 47 patients with complete data of donor and recipient histocompatibility antigens, there were seven patients 14.9% ; with two or fewer HLA mismatches. Among 74 angiograms of 50 patients reviewed, only one patient had discrete stenosis less than 50% in the middle portion of the left anterior descending artery at 1 year after transplantation. The cumulative incidence of transplant CAD was 2% at 1 year and 2% at 2 and 4 years after transplantation.
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1. Canadian Male Sexual Health Council. Erectile Dys function is More Common Than You Might Think. cmshc , accessed October 31, 2003. 2. Erectile dysfunction practice guidelines. Can J Urol 2002; 9 4 ; : 15831587. 3. Hinchliff S, Gott M. Perceptions of WellBeing in Sexual Ill Health: What Role does Age Play? J Health Psychol 2004; 9 5 ; : 649660. 4. Jackson G. Treatment of erectile dysfunction in patients with cardiovascular disease: guide to drug selection. Drugs 2004; 64 14 ; : 15331545. 5. Sadovsky R. Integrating erectile dysfunction treat ment into primary care practice. J Med 2000; 109 Suppl 9A: 22S28S. 6. Rosen RC, Cappelleri JC, Smith MD, Lipsky J, Pena BM. Development and evaluation of an abridged, 5item version of the International Index of Erectile Function IIEF5 ; as a diagnostic tool for erectile dys function. Int J Impot Res 1999; 11 6 ; : 319326. 7. Fazio L, Brock G. Erectile dysfunction: management update. CMAJ 2004; 170 9 ; : 14291437. 8. Levine LA. Diagnosis and treatment of erectile dys function. J Med 2000; 109 Suppl 9A: 3S12S. 9. Anatomy and physiology of erection: pathophysiol ogy of erectile dysfunction. Int J Impot Res 2003; 15 Suppl 7: S5S8. 10. Salonia A, Briganti A, Deho F, Naspro R, Scapaticci E, Scattoni V et al. Pathophysiology of erectile dysfunc tion. Int J Androl 2003; 26 3 ; : 129136. 11. Brock G. Issues in the assessment and treatment of erectile dysfunction: Individualizing and opti mizing treatment for the "silent majority". medscape viewprogram 1826, accessed December 22, 2003. 12. Kim YC. Endocrine and metabolic aspect including treatment. In: Jardin A, Wagner A, Khoury S, et al, editors. Erectile Dysfunction. Paris: Health Publica tion Ltd., 2000: 205240. 13. AACE Male Sexual Dysfunction Task Force. Ameri can Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Evaluation and Treatment of Male Sexual Dysfunction: A Cou ple's Problem 2003 Update. Endocrine Practice 2003; 9: 7795. Nurnberg HG, Seidman SN, Gelenberg AJ, Fava M, Rosen R, Shabsigh R. Depression, antidepressant ther apies, and erectile dysfunction: clinical trials of silde nafil citrate Viagra ; in treated and untreated patients with depression. Urology 2002; 60 2 Suppl 2 ; : 5866. 15. Feldman HA, Goldstein I., Hatzichristou D, et al. Impotence and its medical and psychosocial corre lates: results of the Massachusetts Male Aging Study. J Urol 1994; 151: 5461. Miller TA. Diagnostic evaluation of erectile dysfunc tion. Fam Physician 2000; 61 1 ; : 9510. 17. Corona G, Mannucci E, Mansani R, Petrone L, Barto lini M, Giommi R et al. Organic, relational and psy chological factors in erectile dysfunction in men with diabetes mellitus. Eur Urol 2004; 46 2 ; : 222228. 18. Esposito K, Giugliano F, Di Palo C, Giugliano G, Marfella R, D'Andrea F et al. Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial. JAMA 2004; 291 24 ; : 29782984. 19. Saltzman EA, Guay AT, Jacobson J. Improvement in erectile function in men with organic erectile dysfunc tion by correction of elevated cholesterol levels: a clin ical observation. J Urol 2004; 172 1 ; : 255258. 20. Moore BE, Rothschild AJ. Treatment of antidepres santinduced sexual dysfunction. Hospital Practice 1999; available online at hosppract issues 199901 moore . 21. Labbate LA, Croft HA, Oleshansky MA. Antidepres santrelated erectile dysfunction: management via avoidance, switching antidepressants, antidotes, and adaptation. J Clin Psychiatry 2003; 64 Suppl 10: 1119. 22. Canadian Hypertension Society. Canadian Hyperten sion Education Program. chs.md, accessed Aug 27, 2004. 23. Ranelli PL, Biss J. Physicans' perceptions of commni cation with and responsibilities of pharmacists. J Pharm Assoc 2000; 40: 625630. Rosen RC, Kostis JB. Overview of phosphodiesterase 5 inhibition in erectile dysfunction. J Cardiol 2003; 92 9A ; : 9M18M. 25. Gresser U, Gleiter CH. Erectile dysfunction: compari son of efficacy and side effects of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil - review of the lit erature. Eur J Med Res 2002; 7 10 ; : 435446. 26. Carson CC, Burnett AL, Levine LA, Nehra A. The effi cacy of sildenafil citrate Viagra ; in clinical popula tions: an update. Urology 2002; 60 2 Suppl 2 ; : 1227. 27. Viagra Product Monograph. Compendium of Phar maceuticals and Specialties 2003. Canadian Pharma cists Association; 2003. 28. Cialis Product Monograph. Eli Lilly Canada Inc.; 2003. 29. Levi5ra product monograph. Bayer Canada; 2003. 30. Kirby M. Management of erectile dysfunction in men with cardiovascular conditions. Br J Cardiol 2003; 10: 305307. Kloner RA. Introduction: Erectile dysfunction and cardiovascular risk factors. J Cardiol 2003; 92 9A ; : 12. 32. Fox KM, Thadani U, Ma PT, Nash SD, Keating Z, Czorniak MA et al. Sildenafil citrate does not reduce exercise tolerance in men with erectile dys function and chronic stable angina. Eur Heart J 2003; 24 ; : 22062212. 33. DeBusk RF, Pepine CJ, Glasser DB, Shpilsky A, DeRiesthal H, Sweeney M. Efficacy and safety of.
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Quality Improvement Insights The following are some of the lessons learned from the Tar health center QI team: New problem-solving teams may have a tendency to follow QI steps procedurally. The problem of low utilization does not necessarily lead to drawing a flowchart. If in the process of investigating reasons for low utilization the team had learned that clients found services too slow or disorganized, a flowchart might have been warranted. Instead, it appears that the team drew a flowchart of the service because this procedure was presented in training, rather than due to direct analysis of their problem. Since Rwandese teams have found systematic team problem solving difficult to conceptualize initially, this procedural approach may have been necessary during a team's first cycle. In such cases, the cycle should be followed by a facilitator-led team analysis of the problem-solving process. This manner would better enable teams to judge the utility of a flowchart in future cycles. The unexamined process can always be improved. The team changed how IEC was conducted at the health center and improved client orientation at reception. The result was that the health center measured a decrease in waiting times from three hours to an hour. Thus, even though clients did not specifically comment on waiting times, the flowchart exercise led to improving the quality of services to benefit clients. Quality improvement can improve the dialogue between providers and the community. Team members did not expect that the high cost of drugs was a major obstacle for the community. The lesson one may take from this is that health center staff are not always aware of what clients need, even though they work with them everyday. This realization led to the installation of a suggestion box, which clients have since used to share both complaints and praise. Comments on the problem-solving experience from Tar included.
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Pean tick-borne encephalitis vaccinations.30, 33 It is of note that the incidence of a measles vaccinationassociated ADEM is about 10 to 20 per 100 000 vaccinated individuals and thus considerably lower than the incidence of ADEM after a wild-type measles encephalitis 100 per 100 000 infected individuals ; Table 1 ; . A number of infectious agents, mainly viruses, have been associated with ADEM and are summarized in Table 1. Clinical signs and symptoms of ADEM may manifest themselves parainfectiously or postinfectiously. Typically, there is a latency of 7 to days between a febrile illness and the onset of neurological symptoms. In the case of vaccination-associated ADEM, this latency period may be longer. The recognition of the temporal association between a vaccination or infection and the appearance of neurological signs and symptoms is critical.
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