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1980 1982 1987 B.A. with honors M.S. Ph.D. Physician Scientist Program M.D. Kenyon College, Gambier, Ohio The Ohio State University, Columbus, Ohio The Ohio State University, Columbus, Ohio University of Miami Medical School, Miami, Florida Dartmouth Medical School, Hanover, New Hampshire.
Researcher. Hinshaw said he and his colleagues did not expect the "breadth of impairment" they found. The team began the study with 228 girls: 140 had ADHD, while 88 did not. Five years later, researchers conducted a follow-up study involving 209 of the girls, who had entered middle and high school. In nearly a dozen areas examined by researchers -including academic performance, prevalence of eating disorders, relationships with peers and teachers, and organizational skills -- the girls with ADHD were significantly more likely to have problems than those in a matched control group who did not have the disorder. The gap in reading and math ability had widened in five years and new concerns had emerged: About 30 percent of the girls with ADHD were at least mildly depressed, compared with 10 percent of the control group, Hinshaw said. The same percentages were seen in substance abuse. One area showed marked improvement: The girls in the ADHD group showed fewer signs of hyperactivity as they grew older, the same trend seen among boys in other studies. Pelham called Hinshaw's results "very important" because so little is known about teenage girls with ADHD. Too often, he said, the problem is either overlooked or misdiagnosed as depression. A long-term study published in May by researchers at Massachusetts General Hospital in Boston found that teenage girls with ADHD were more likely to have mood or anxiety disorders than those without the disorder. "Most girls do as well as boys" when their ADHD is treated, Pelham said. The optimal treatment combines the use of stimulant medications, such as Ritalin or Adderall, with behavioral therapy that provides structure, teaches organizational skills and rewards desired actions, experts say. To Washington area developmental pediatrician Patricia Quinn, who has specialized in the treatment of ADHD for nearly 30 years, the results of Hinshaw's study serve as a warning. "People think if a girl is ditzy she's not going to have serious problems, but this study confirms that's not true, " said Quinn, who has co-authored books about girls and women with ADHD. Molly Zametkin, 18, a recent graduate of Walter Johnson High School in Bethesda, knows firsthand that girls can be as affected as boys, even if their problems seem less obvious. First diagnosed in elementary school, Zametkin, who described herself as "a little space cadet who was never hyperactive, " vehemently fought her parents' efforts to treat ADHD with medication and therapy. Her father is a research psychiatrist at the National Institute of Mental Health. Only after years of struggling in school, Zametkin said, did she accept that "it was a problem I couldn't fix by myself"; she began taking medication regularly when she started high school. The Berkeley findings, she said, mirror aspects of her experience as well as what she sees in other girls who have ADHD, especially their battles with food and their use of drugs, alcohol and cigarettes and allegra.
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Clinical Coordinating Center: Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL; Principal Investigator and Director: Edmund J. Lewis, MD; Co-Principal Investigator and Associate Director: Tomas Berl, MD, University of Colorado Health Science Center, Denver, CO; Project Coordinator and Director of Central Laboratory: Richard D. Rohde, BS, Chicago, IL; Associate Project Coordinator: Elizabeth Muskwe, Chicago, IL. European Clinical Coordinating Center: University of Heidelberg, Heidelberg, Germany; Director: Professor Eberhard Ritz, MD; Associate Director: Luis Ruilope, MD, Hospital 12 de Octubre, Madrid, Spain; Medical Consultant: Pieter Klooker, MD, Heidelberg, Germany; Project Coordinator: Beatrix Spiller, PharmD, Heidelberg, Germany. Pacific Clinical Coordinating Center: Monash Medical Center, Clayton, Victoria, Australia; Director: Professor Robert Atkins, MD; Associate Director: George Jerums, MD, Austin & Repatriation Medical Center, Heidelberg, Victoria, Australia; Project Coordinator: Raphael Bartholomeusz, PhD, Clayton, Victoria, Australia.
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Acknowledgements This research was supported by The Department of Veterans Affairs Medical Research Service, NIHrNIAAA AA09850, and the USIsrael Binational Science Foundation 94-00062. We also acknowledge the generous donation of IL-1b from the National Cancer Institute ZBiological Response Modifiers Program, NIHrNCI. The expert technical assistance of Mr. Ngy Heng and Khai Nguyen was also greatly appreciated and ambien and adderall, for example, side affects of adderall.
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